Allergic Diseases

Question: Which is the first line of defense against infection?


Innate immunity is the first line of defense against infection because its elements are already present in the circulation and can respond immediately to microbial invasion. However, the innate system has no memory; on subsequent exposure to the same antigen, the response is no greater, no faster, and no more effective than it was on first exposure to antigen.

Reference:  Adkinson NF, Yunginger A, Busse W, et al (eds): Middleton’s Allergy: Principles and Practice, 6th ed. St. Louis, Mosby, 2004.

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