Allergic Diseases

Question: What two signals are required to activate naive T cells?


The first signal is provided by antigenic peptides displayed in MHC molecules. The second is provided by one or more costimulatory molecule produced by the antigen-presenting cell, in response to molecules displayed by pathogens. If these costimulatory signaling molecules are not present, the T cell-MHC interaction may alternatively cause the T cell to undergo programmed cell death, a process known as apoptosis.

Reference: Paul WE (ed): Fundamental Immunology, 5th ed. Philadelphia, Lippincott Williams & Wilkins, 2003.

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